“A peste, fame et bello libera nos, Domine!” Disease, hunger, war, and religion have shaped human existence over many centuries. This volume of RCC Perspectives presents exciting syntheses between research in the fields of archaeology, anthropology, and history; moving from prehistory to the medieval period, six chapters look at humanity’s struggles with subsistence, religious belief, ill-health, death, and warfare in a variety of global landscapes, and show how, by sharing expertise and combining methodological approaches, we can advance our understanding of our common past.